Side effects of amrinone therapy.

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Side effects of amrinone therapy.

We gave intravenous amrinone to 40 patients in heart failure, and oral amrinone to 18 patients. Acute intravenous administration caused a significant reduction in mean blood pressure and this was severe enough to require correction by plasma infusion in five patients. Oral amrinone was accompanied by thrombocytopenia in 10 patients but no complications were associated with the low platelet coun...

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Side effects of vasodilator therapy.

Vasodilating antihypertensive drugs have in common the capacity to activate the peripheral sympathetic nervous system through the carotid sinus baroreceptor reflex mechanism, thereby increasing heart rate, renin release, and sodium and water retention. They differ in their tendencies to augment cardiac output and to relieve or precipitate cardiac failure and arrhythmias. Vasodilating antihypert...

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Glucocorticoid therapy: minimizing side effects.

OBJECTIVE To describe the main undesirable side effects of glucocorticoid therapy, mechanisms of action and the necessary measures to minimize side effects. SOURCES Author's experience, supplemented with papers published in MEDLINE. SUMMARY OF THE FINDINGS The principles for minimizing undesirable side effects of glucocorticoid therapy include: a) only use glucocorticoids if they are essent...

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Effects of intracoronary and intravenous amrinone

The effects of intracoronary and intravenous infusions of amninone were studied to distinguish the drug's direct cardiac actions from its peripheral vascular and neuroendocrine properties. Intracoronary infusions of amrinone were found to have no haemodynamic effect other than producing a slight reduction in the left ventricular ejection fraction and some suggestion of coronary vasodilatation i...

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Side effects with amiodarone therapy.

Amiodarone hydrochloride is increasingly being used in the treatment of ventricular and supraventricular arrhythmias. Although a highly effective anti-arrhythmic agent, its use is restricted by the high incidence of side effects. To elucidate the value of monitoring serum level of both the parent drug and its active metabolite in predicting the occurrence of side effects, the investigators exam...

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ژورنال

عنوان ژورنال: Heart

سال: 1983

ISSN: 1355-6037

DOI: 10.1136/hrt.50.5.499